The Giants entered the clash with Melbourne having won just two out of 16 games at the MCG.
They ended up 26-point winners in a comprehensive display, all but putting to bed their hoodoo at the venue that hosts the Grand Final.
Melbourne kicked just one goal in the first half as the Giants ran out the contest to deliver a 14.10 (94) to 10.8 (68) victory.
Having struggled at the ground they may return to in September, they seemed to have fixed whatever had been plaguing them there.
Josh Kelly led the way, racking up 31 disposals, while Tim Taranto (32) and Jacob Hopper (23) made their contributions in the clinches.
Up front, the trio of Jeremy Cameron, Harry Himmelberg and Jeremy Finlayson continued chugging along, meshing well and giving the Giants potency.
One play which displayed their cohesion came during the second term. Toby Greene sent a long ball to Himmelberg’s advantage out the back, but instead of going for the mark, he opted to tap it into Cameron’s path, which the Coleman Medal leader duly collected and put through.
Himmelberg kicked one goal in the first half before filling his boots to end with a career-best haul of five in his 50th AFL game.
