Josh Jackson was impressive with 64 tackles and a tackle efficiency of 100 per cent, while Will Hopoate ran for over 170 metres and centre Nick Cotric came up with 10 tackle breaks.
Penrith opened the scoring through Viliame Kikau who collected a pass from Jarome Luai down their left-hand side.
The Dogs looked to have hit back when Corey Allan collected a Nick Cotric kick to score, but after being awarded the try, the bunker overturned the on-field decision because of a knock-on in the lead up to Allan scoring.
Then just before halftime, Tyrone May collected a Luai kick to put the Panthers up 10-0 at the break.
The visitors ran in three second half tries to get the win after winger Dallin Watene-Zelezniak was placed on report for a high tackle on Nathan Cleary.
Though disappointed, coach Trent Barrett said he thought Canterbury was really competitive for long periods.
“Had that try gone our way in the first half it would have given us the confidence,” he said.
“The Panthers showed their class in just how good a side they are; they had 46 sets of the ball to our 29, you can’t compete when that’s going against you.
“But there were still some holes in our game.
“We have to get back to training and aim to improve it. We need to get an even share of the ball and not make unforced errors.”
The Bulldogs take on the Broncos at Suncorp Stadium in Brisbane from 5.30pm on Saturday.
