When firefighters arrived about 2pm they found thick black smoke issuing from the rear of the home, with the fire threatening a neighbouring property.
All residents have been evacuated from the home.
NSW Police and NSW Ambulance are also on scene. Traffic in the area is impacted with Quigg St closed as emergency services continue to render the area safe.
FRNSW have received dozens of calls in relation to this fire and would like to thank the community for coming forward and using the Triple Zero (000) service.
Calling Triple Zero (000) is the quickest way to get the right resources to assist you in a fire emergency and can often be the difference between life and death, or a building being saved or destroyed.
Fire destroys home
Fire has destroyed a home on Quigg Street, Lakemba, with more than 20 firefighters battling the blaze to stop it spreading to nearby homes.