About 11.20pm, emergency services were called to Henry Lawson Drive, Georges Hall, following reports of a crash, involving a truck and a motorcycle.
The motorcycle rider was treated on scene by NSW Ambulance paramedics; however, he died at the scene. The man has not been formally identified.
The 43-year-old male truck driver was also treated on scene before being taken to hospital for mandatory testing.
The road was closed for almost eight hours as police began investigating the circumstances surrounding the incident.
Anyone with dash cam footage or information is urged to contact Bankstown police or Crime Stoppers on 1800 333 000.
Fatal two-vehicle crash in Georges Hall
INVESTIGATIONS are continuing after a fatal two-vehicle crash in Georges Hall overnight.