About 10.40pm (Sunday, August 4), emergency services were called to Davies Road, Padstow, following reports of a two-vehicle crash.
When Bankstown Police arrived they found a white Audi alight after colliding with a silver Nissan.
Fire and Rescue NSW extinguished the blaze.
Police were told the occupants of the Audi – believed to be three men – left the scene before police arrival.
The driver of the Nissan, a 39-year-old man, was treated by paramedics before being taken to hospital in a critical condition.
A crime scene has been established and specialist officers from the Crash Investigation Unit commenced an investigation into the circumstances surrounding the crash.
As inquiries continue, anyone with information, CCTV or dashcam footage is urged to contact Bankstown Police Area Command or Crime Stoppers on 1800 333 000.
Man fighting for life as police hunt three men
A MAN is fighting for his life and a manhunt is underway for three men after a horrific crash in Padstow last night.