The 25-year-old was hit by a car on Woodstock Street at 10pm, before it was driven from the scene toward Marian Street.
The man was treated by paramedics before being taken to hospital in a critical condition.
Police are urging anyone who may have information, dashcam footage from the area, or who may have witnessed the incident, to contact Crime Stoppers, 1800 333 000 or nsw.crimestoppers.com.au.s
Witness appeal after pedestrian seriously hurt in alleged hit, run
POLICE are appealing for help after a pedestrian was critically injured in an alleged hit and run in Guildford on Saturday night.