About 2.20am today (Thursday, December 9), police allegedly attempted stop the pair who were allegedly not wearing helmets while travelling on Homebush Bay Drive.
Police said a pursuit was initiated but terminated due to the manner of driving.
The motorcycle was later located at the intersection of Parramatta and St Hilliers Roads at Auburn, after colliding with two taxis, with both riders suffering serious injuries.
The men were treated at the scene by paramedics before being taken to hospital.
The drivers of each taxi were uninjured and taken to hospital for mandatory testing.
A critical incident team will now investigate the circumstances surrounding the crash and that investigation will be subject to independent review.
Anyone with information about this incident is urged to contact Crime Stoppers: 1800 333 000 or https://nsw.crimestoppers.com.au.
